Ketamine: Dosing Considerations and Implications
Intravenous Administration
Ketamine is commonly administered intravenously (IV) at a dose of 0.5 mg/kg. However, the benefits and adverse effects are likely dose-dependent.
Subcutaneous Administration
Subcutaneous (SC) ketamine has also been administered to both unipolar and bipolar patients. The dosing regimen may involve single or multiple doses, administered weekly or twice-weekly.
Dose Range
For the first dose, 5.6 mg (or two sprays) is recommended. Depending on the patient's response, the dose may be gradually increased to 8.4 mg.
Treatment Indications
Ketamine has been shown to be effective in the treatment of treatment-resistant depression (TRD). It has also been used for other indications, such as post-traumatic stress disorder (PTSD) and chronic pain.
Adverse Effects
The use of ketamine can be associated with a range of adverse effects, including: * Dissociative symptoms * Nausea and vomiting * Hallucinations * Agitation * Increased blood pressure and heart rate It is important to carefully monitor patients during and after ketamine administration to minimize the risk of adverse events.
Reference
* Jelen, J., & Stone, J. M. (2018). Ketamine: Dosing, indications, interactions, adverse effects, and more.
Psychiatric Times.
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